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This review aims at providing an overview of these concepts and their potential inter-relationships in the development of insulin resistance, with particular regard to changes in adipose organ and skeletal muscle. New findings also connect insulin resistance to extensive … Diabetes 64(7):2346–2351. a decreased responsiveness to the metabolic actions of insulin in AT, muscle, liver, and endothelial and immune cells , . Barazzoni R, Cappellari GG, Ragni M, Nisoli E (2018) Insulin resistance in obesity: An overview of fundamental alterations.

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